How does Salvia affect the brain?
Fulvio Bruno
2025-05-05 08:43:14
Numero di risposte: 2
Salvia's primary psychoactive component, salvinorin A, is a kappa opioid receptor agonist capable of eliciting powerful alterations in visual perception, thinking, mood, and behavior.
Short-term effects of salvia include brief yet intense hallucinations, feelings of detachment from the physical body, and other changes in perception, sensation, and mood.
Higher doses of salvia can lead to increasingly intense hallucinations and cognitive changes, as well as heightened levels of physical and psychological distress.
When smoked, the effects begin very quickly and last for approximately half an hour, while ingestion by chewing the leaves takes 5 to 10 minutes to take effect.
The drug causes a general detachment from reality and a decreased ability to interact with physical surroundings, raising concerns about dangerous situations such as driving under its influence.
Although research is lacking, long-term effects of salvia remain largely unknown, but prolonged use may potentially result in a substance use disorder.
Gianleonardo Fontana
2025-04-26 05:42:10
Numero di risposte: 1
Salvia affects structures in the brain called opioid receptors.
This makes salvia different from other hallucinogenic drugs like LSD and mushrooms, which affect the brain's levels of a chemical called serotonin.
Salvia's effects on the mind can range from mild to intense, including hallucinations and changes in visual perception.
It can cause a sense of detachment from self and reality (not being able to tell the difference between what's real and what's imagined).
Some studies suggest that, over time, salvia use may contribute to a condition called dysphoria that is characterized by feelings of depression, discontent, and restlessness.
Carmela Pellegrino
2025-04-17 08:25:12
Numero di risposte: 1
Salvia divinorum increases the communication across parts of the brain.
Salvinorin A results in more random or disconnected signaling within the default mode network, which is the part of the brain most active when a person is sitting still, relaxing, daydreaming or otherwise not engaged in externally directed mental exercise.
Salvinorin A produces powerful out-of-body and amnesia-like experiences over a short time frame similar to the effects of nitrous oxide.
Most of the fMRI-scanned networks seemed to communicate more with one another when influenced by salvinorin A than when the drug was not present, but they communicated less within themselves.
The researchers observed particularly decreased synchronization of the default mode network, meaning that the brain’s electrical signals became more random and unpredictable.
Elsa Ferrara
2025-04-17 07:04:13
Numero di risposte: 1
Salvinorin A, salvia’s active ingredient, impacts the brain in unclear ways. It’s thought that this ingredient attaches to the nerve cells in your body to create a variety of hallucinogenic effects. The effects of salvia on your brain may include visual and auditory hallucinations, such as seeing bright lights, vivid colors, or extreme shapes.
Other effects include distorted reality and altered perceptions of surroundings, as well as feeling as if you’re having an “out-of-body” experience or feeling detached from reality. Some people may also experience slurred speech, laughing uncontrollably, or anxiety from a “bad trip.”
A 2011 animal study found that salvia use may have negative effects on learning and impair long-term memories. These effects may occur rapidly, within just 5 to 10 minutes of smoking or inhaling the drug.
Vittorio Carbone
2025-04-17 06:41:36
Numero di risposte: 1
Salvia divinorum's active component, salvinorin A, travels through the brain extremely fast, peaking within 40 seconds of administration—nearly 10 times faster than cocaine.
High concentrations of the drug localize to the cerebellum and visual cortex, affecting motor function and vision.
The effects described by users include an almost immediate high that starts fading within 5–10 minutes, distinguishing it from other hallucinogens due to its rapid onset and short duration.
Unlike LSD, Salvia doesn't typically induce euphoria but targets receptors that modulate pain and may have therapeutic potential for mood disorders.
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